MYCOBACTERIA WITH MANNOSE CAP-DEFICIENT LIPOARABINOMANNAN
摘要
The present invention relates to mycobacterial lipoarabinomannan cap-specific mannosyl transferases and nucleic acid encoding such transferases. The invention further relates to Mycobacteria in which the lipoarabinomannan cap-specific mannosyl transferases have been inactivated and that therefore express mannose cap-deficient lipoarabinomannan. Such Mycobacteria with mannose cap-deficient lipoarabinomannan may be used as more effective vaccines against mycobacterial diseases as they lack the immunosuppressive action of the mannose cap.
申请公布号
WO2006078164(A3)
申请公布日期
2007.01.25
申请号
WO2006NL50013
申请日期
2006.01.18
申请人
VERENIGING VOOR CHRISTELIJK HOGER ONDERWIJS, WETENSCHAPPELIJK ONDERZOEK EN PATIENTENZORG;APPELMELK, BERNARD JAN;BITTER, WILHELMUS;VAN DER LEY, PETER, ANDRE
发明人
APPELMELK, BERNARD JAN;BITTER, WILHELMUS;VAN DER LEY, PETER, ANDRE