ERR? PEPTIDE FRAGMENT COMPLEXES AND USES THEREOF IN DRUG DISCOVERY

摘要

The present invention includes a method for the identification of novel compounds that interact and stabilize the ligand binding domain of ERR?, a methodology for producing diffraction quality crystal structures in the presence of antagonist and agonist ligands and the identification of novel biologically-active compounds that have an effect on the transcriptional-activating activity of ERR?.