| 摘要 |
PROBLEM TO BE SOLVED: To obtain a new olefin derivative useful as a medicine and to find the new pharmacological action of the derivative. SOLUTION: The compound is represented by general formula [I] (X is a benzene ring, a cycloalkane ring or an aromatic heterocycle; Y is a pyridine ring or 1H-pyrrolo[2,3-b]pyridine ring; R<SP>1</SP>and R<SP>2</SP>are each a hydrogen atom or an alkyl group; R<SP>3</SP>and R<SP>4</SP>are each a halogen atom, H, a hydroxy group, an alkoxy group, an aryloxy group, an alkyl group, an aryl group, an amino group, an alkylamino or an arylamino group; and R<SP>5</SP>and R<SP>6</SP>are each a halogen atom, H, a hydroxy group, an alkoxy group, an aryloxy group, an alkyl group, an aryl group, a carboxy group, its ester, its amide, a nitro group or a cyano group) and is useful as a therapeutic agent for diseases associated Rho kinase, especially a therapeutic agent for eye diseases such as glaucoma, etc. COPYRIGHT: (C)2007,JPO&INPIT
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