| 摘要 |
<p>Solubility, absortion, and permeability of drugs upon oral administration are improved when the drugs are mixed and/or complexed with water-miscible organic solvents. Illustratively, the absortion of a heparin-deoxycholic acid conjugate upon oral administration is increased by mixing and/or complexing this conjugate with dimethyl sulfoxide. Other illustrative water-miscible organic solvents include N-methypyrrolidone, polyoxyl 35 castor oil, diethylene glycol monoethyl ether, and benzoic acid.</p> |
