A coating for a medical device, the device generally being of the type which is to be used internally in a subject, includes a transglutaminase (TGase) inhibitor. The Tgase inhibitor effectively prevents the activity of any Tgase involved in clot formation or clot stability. Preferably, the transglutaminase inhibitor is a factor XIIIa inhibitor. The coating may be prepared by suitable processes such as esterification. The coating may be immobilized on a suitable medical device in a number of ways and is preferably included in a TGase inhibitor containing polymer. The coating may also include a suitable antimicrobial agent.
申请公布号
WO2007010201(A2)
申请公布日期
2007.01.25
申请号
WO2006GB02587
申请日期
2006.07.12
申请人
ASTON UNIVERSITY;LAMBERT, PETER, A.;GRIFFIN, MARTIN;COLLIGHAN, RUSSELL;RATHBONE, DANIEL, LEE
发明人
LAMBERT, PETER, A.;GRIFFIN, MARTIN;COLLIGHAN, RUSSELL;RATHBONE, DANIEL, LEE