The invention is directed to techniques for optically detecting changes in concentration of analytes in the body of a patient via fluorescent resonant energy transfer (FRET). An analyte detector implantable in the body of the patient includes a plurality of fluorophore-tagged sensing elements that bind to a specific analyte. A light emitter emits energy at a wavelength that is within the absorption spectrum of a donor fluorescent dye, and a light detector detects the energy fluoresced by donor and acceptor fluorescent dyes in the analyte detector. The relative intensity of energy fluoresced by the dyes is a function of the concentration of the analyte. A processor monitors the change in concentration of the analyte over time and may take action, such as directing the therapy device to administer therapy, when the change in concentration surpasses a predetermined threshold.
申请公布号
WO2005043157(A3)
申请公布日期
2007.01.25
申请号
WO2004US34777
申请日期
2004.10.19
申请人
MEDTRONIC, INC.;GRANT, SHEILA, A.;SOYKAN, ORHAN;LICHLYTER, DARCY, J.
发明人
GRANT, SHEILA, A.;SOYKAN, ORHAN;LICHLYTER, DARCY, J.