Preparation of benzene compound comprises reacting a benzene compound with a halo compound in the presence of a base and e.g. nickel-, palladium- compound, metallic nickel or palladium

摘要

Preparation of benzene compound (I) comprises reacting a benzene compound (II) with a halo compound (III) in the presence of a base and nickel-, palladium- compound, metallic nickel or palladium, or one or more ligand of phosphine-, arsenic-, tertiary alkylamine- or carbene. Preparation of benzene compound of formula (I) comprises reacting a benzene compound of formula (II) with a halo compound (III) of formula (A(X)n) in the presence of a base and nickel-, palladium- compound, metallic nickel or palladium, or one or more ligand of phosphine-, arsenic-, tertiary alkylamine- or carbene. Y1>OH, OR, SH, SR or NR2; either R : 1-30C-alkyl or 3-30C-cyclic alkyl optionally substituted by R3> (where one or more non-adjacent carbon atoms indirectly bonded to heteroatoms of Y1> are substituted by N-R3>, O, S, O-CO-O, CO-O, CO-NR3>, CR3>=CR3> or -C?=C, and one or more hydrogen atom are substituted by F or CN); and R1>Si(R3>)3, OH, 1-30C alkyl or -alkoxy, 3-30C cyclic alkyl or -alkoxy (optionally substituted by R3>, where one or more non-adjacent carbon atoms are substituted by N-R3>, O, S, O-CO-O, CO-O, CO-NR3>, CR3>=CR3> or -C?=C, and one or more hydrogen atom are substituted by F or CN) or (hetero)aromatic ring system (optionally substituted by one or more non-aromatic groups of R1>) or a combination of 2-4 of ring systems; and R2>H, F, CN or R1>; or R+R1>, R+R2>mono- or poly- cyclic ring system; or R1>+R, R1>+R2>mono- or polycyclic, aliphatic, aromatic or heteroaromatic ring system; R3>H or 1-20C-aliphatic or aromatic hydrocarbon; A : 1-30C alkyl, 3-30C cyclic alkyl (optionally substituted by R3>, where one or more non-adjacent carbon atoms are indirectly bonded to the benzene by N-R3>, O, S, O-CO-O, CO-O, CO-NR3>, CR3>=CR3> or -C?=C and one or more hydrogen atom are substituted by F or CN), vinyl group, (hetero)aromatic ring system (optionally substituted by one or more non-aromatic remainders of R2>) or a combination of 2-4 of ring systems; n : >=1 or maximum number of substitutable H atoms at group A; and X : Cl, Br, I, alkylsulfonate, arylsulfonate, triflate, nonaflate or diazonium salt. When R1> and R2> has unequal hydrogen in ortho position to the substituent Y1>, then (I) is a simple benzene derivative. [Image].