发明名称 |
PLEIOTROPHIN-BINDING OR NONBINDING CHONDROITIN SULFATE/DERMATAN SULFATE OLIGOSACCHARIDE |
摘要 |
<p><P>PROBLEM TO BE SOLVED: To provide a new sulfated oligosaccharide useful as a reagent for study for elucidating the structure and function of chondroitin sulfate and dermatan sulfate having various kinds of bioactivities. <P>SOLUTION: The pleiotrophin (PTN)-binding or nonbinding sulfated oligosaccharide is isolated and purified by fragmenting chondroitin sulfate/dermatan sulfate hybrid chain (E-CS/DS) derived from embryonic pig brain, and subjecting the resultant fragments to an affinity chromatography or the like using a column for immobilizing the PTN which mediates neurite extension-promoting activities. Structures of many kinds of new sulfated oligosaccharides are determined by subjecting the resultant oligosaccharides to structural analysis. The PTN-binding sulfated oligosaccharide in them can be utilized as a PTN function regulator for binding with the PTN and regulating the function. <P>COPYRIGHT: (C)2007,JPO&INPIT</p> |
申请公布号 |
JP2007016099(A) |
申请公布日期 |
2007.01.25 |
申请号 |
JP20050197587 |
申请日期 |
2005.07.06 |
申请人 |
JAPAN SCIENCE &, TECHNOLOGY AGENCY |
发明人 |
SUGAWARA KAZUYUKI;BAO XINGFENG |
分类号 |
C08B37/08;A61K31/737;A61P43/00 |
主分类号 |
C08B37/08 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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