发明名称 |
Addition salts of azithromycin and citric acid and process for preparing them |
摘要 |
Said addition salts have a molar ratio between azithromycin and citric acid such as to provide a pH comprised between 4.0 and 8.0 in a 10% aqueous solution. The process for preparing said salts comprises: a) dissolving azithromycin in a solvent or mixture of solvents; b) adding citric acid; and c) isolating the product obtained by crystallisation. The addition salts of azithromycin and citric acid are stable and soluble in aqueous medium, being useful antibacterial and antiprotozoan agents.
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申请公布号 |
US2007021359(A1) |
申请公布日期 |
2007.01.25 |
申请号 |
US20050558801 |
申请日期 |
2005.11.29 |
申请人 |
COSME GOMEZ ANTONIO;PALOMO NICOLAU FRANCISCO E |
发明人 |
COSME GOMEZ ANTONIO;PALOMO NICOLAU FRANCISCO E. |
分类号 |
A61K31/7052;A61K31/7048;C07H17/08 |
主分类号 |
A61K31/7052 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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