| 摘要 |
The invention concerns compounds of general formula (I), wherein n is equal to 0, 1, 2 or 3; the pyrrolopyridine ring is a pyrrolo[3,2-b]pyridine group, a pyrrolo[3,2-c]pyridine group, a pyrrolo[2,3-c]pyridin group; the pyrrolopyridine ring being optionally substituted in carbon position 4, 5, 6 and/or 7 by one or several substituents X, identical or different; Z<SUB>1</SUB>, Z<SUB>2</SUB>, Z<SUB>3</SUB>, Z<SUB>4</SUB> and Z<SUB>5</SUB> represent, independently of one another, a hydrogen or halogen atom or a C<SUB>1</SUB>-C<SUB>6</SUB>-alkyl, C<SUB>3</SUB>-C<SUB>7</SUB>- cycloalkyl, C<SUB>3</SUB>-C<SUB>7</SUB>-cycloalkyl-C<SUB>1</SUB>-C<SUB>3</SUB>-alkylene, C<SUB>1</SUB>-C<SUB>6</SUB>-fluoroalkyl, C<SUB>1</SUB>-C<SUB>6</SUB>-alkoxyl, C<SUB>1</SUB>-C<SUB>6 </SUB>-fluoroalkoxyl, cyano, C(O)NR<SUB>1</SUB>R<SUB>2</SUB>, nitro, NR<SUB>1</SUB>R<SUB>2</SUB>, C<SUB>1</SUB>-C<SUB>6</SUB>-thioalkyl, -S(O)-C<SUB>1</SUB>-C<SUB>6</SUB>-alkyl, - S(O)<SUB>2</SUB>-C<SUB>1</SUB>-C<SUB>6</SUB>-alkyl, SO<SUB>2</SUB>NR<SUB>1</SUB>R<SUB>2</SUB>, NR<SUB>3</SUB>COR<SUB>4</SUB>, NR<SUB>3</SUB>SO<SUB>2</SUB>R<SUB>5</SUB>, aryl-C<SUB>1</SUB>-C<SUB>6</SUB>-alkylene or aryl, aryl and aryl-C<SUB>1</SUB>-C<SUB>6</SUB>-alkylene group being optionally substituted; W presents a fused bicyclic group of formula (a), bound to the nitrogen atom by positions 1, 2, 3 or 4; A represents an optionally substituted 5 to 7-membered heterocycle comprising one to three heteroatoms selected among O, S or N; in base or acid addition salt form, or in hydrate and solvate form. The invention also concerns a method for preparing said compounds and their therapeutic use. |
