| 发明名称 |
DUAL-TRANSFECTED CELLS LINES AS IN VITRO SCREENING TOOLS FOR PHARMACEUTICAL COMPOUND PROFILING: A MODEL FOR HEPTOBILIARY ELIMINATION. |
| 摘要 |
<p>The invention is referring to several dual-transfected cell lines expressing human NTCP (Na/taurocholate Cotransporting Protein; SLC10A1) together with human BSEP (Bile Salt Export Pump; ABCB11) or human MRP2 (Multidrug Resistance Protein; ABCC2) suitable as an in vitro tool for pharmaceutical compound profiling particularly as a model for hepatobiliary elimination.</p> |
| 申请公布号 |
MXPA06011710(A) |
申请公布日期 |
2007.01.25 |
| 申请号 |
MX2006PA11710 |
申请日期 |
2005.04.08 |
| 申请人 |
SANOFI-AVENTIS DEUTSCHLAND GMBH |
发明人 |
STEFAN THEIS;TANJA EISENBLAETTER |
| 分类号 |
C07K14/435;C07K14/47;C07K14/705;C12N5/00;G01N33/50;G01N33/68 |
主分类号 |
C07K14/435 |
| 代理机构 |
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代理人 |
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