Compounds and methods for treatment of amyloid-B-peptide related disorders

摘要

The present invention relates to compounds, preparation and uses thereof, particularly in the pharmaceutical industry. The present invention discloses novel compounds of the following formula (I)
more particularly useful for the treatment of Alzheimer's disease and other similar diseases, and more specifically the inventive compounds modulate (in particular, inhibit) the level of amyloid-² peptide (A²) exhibited by cells or tissues; A² peptide is a major component of the amyloid plaques found in the brains of Alzheimer's sufferers. This invention also relates to the use of these inhibitors to prevent, treat or ameliorate the symptoms of Alzheimer's disease or any Amyloid-²-Peptide Related Disorder.