发明名称 |
COMPOUNDS FOR PROTEASOME ENZYME INHIBITION |
摘要 |
<p>Peptide-based compounds including heteroatom-containing, three-membered rings efficiently and selectively inhibit specific activities of N-terminal nucleophile (Ntn) hydrolases. The activities of those Ntn having multiple activities can be differentially inhibited by the compounds described. For example, the chymotrypsin-like activity of the 20S proteasome may be selectively inhibited with the inventive compounds. The peptide-based compounds include at least three peptide units, an epoxide or aziridine, and functionalization at the N-terminus. Among other therapeutic utilities, the peptide-based compounds are expected to display anti-inflammatory properties and inhibition of cell proliferation.</p> |
申请公布号 |
EP1745064(A2) |
申请公布日期 |
2007.01.24 |
申请号 |
EP20050735686 |
申请日期 |
2005.04.14 |
申请人 |
PROTEOLIX, INC. |
发明人 |
SMYTH, MARK S.;LAIDIG, GUY J.;BORCHARDT, RONALD T.;BUNIN, BARRY A.;CREWS, CRAIG M.;MUSSER, JOHN H.;CHABALA, JOHN CLIFFORD |
分类号 |
C07K5/087;A61K38/06;C07K5/08 |
主分类号 |
C07K5/087 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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