Vagus nerve stimulation by electrical signals for controlling cerebellar tremor

摘要

The present invention provides a neurostimulator system for alleviating cerebellar tremor, in particular, associated with multiple sclerosis, comprising a programmable electrical pulse generator; and at least one electrode connected with the programmable electrical pulse generator; and wherein the programmable electrical pulse generator is programmed to generate electrical signals with the following parameters: a current magnitude of not above 3 mA, in particular, not above 1 mA, a stimulation signal on-time to signal off-time ratio in the range of about 2:1 to about 1:2, and signal on-times and off-times in the range of about 10 seconds to about 5 minutes, a signal frequency below 30 Hz, and a pulse width within the interval of 50 µs to 500 µs. The invention also provides a method for manufacturing a neurostimulator system intended for alleviating cerebellar tremor associated with multiple sclerosis, comprising providing a programmable electrical pulse generator; programming the programmable electrical pulse generator to generate electrical signals and providing at least one electrode connected with the programmable electrical pulse generator for applying the electrical signals generated by the electrical pulse generator to a cranial nerve, in particular, the vagus nerve, for controlling cerebellar tremor.