发明名称 |
USE OF IMMUNE MODULATORS FOR MAKING MEDICAMENTS OT INHIBIT IMMUNE RESPONSES AGAINST CO-ADMINISTERED RECOMBINANT VIRUSES |
摘要 |
A method of reducing immune response during gene therapy is provided which involves co-administration of the viral vector bearing a therapeutic transgene and a selected immune modulator capable of inhibiting the formation of neutralizing antibodies and/or CTL elimination of the vectors upon repeated administration. |
申请公布号 |
EP0811073(B1) |
申请公布日期 |
2007.01.24 |
申请号 |
EP19960909589 |
申请日期 |
1996.02.23 |
申请人 |
THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA;THE WISTAR INSTITUTE OF ANATOMY & BIOLOGY |
发明人 |
WILSON, James, M.;YANG, Yiping;TRINCHIERI, Giorgio |
分类号 |
C12N15/09;C12N15/86;A61K31/675;A61K35/76;A61K38/00;A61K38/20;A61K38/21;A61K39/12;A61K39/235;A61K39/395;A61K45/00;A61K48/00;A61P37/00;C12N15/861 |
主分类号 |
C12N15/09 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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