发明名称 |
CHEMICAL LINKERS AND CONJUGATES THEREOF. |
摘要 |
<p>The present disclosure provides drug-ligand conjugates that are potent cytotoxins, wherein the drug is linked to the ligand through either a peptidyl, hydrazine, or disulfide linker. The disclosure is also directed to compositions containing the drug-ligand conjugates, and to methods of treatment using them.</p> |
申请公布号 |
MXPA06013413(A) |
申请公布日期 |
2007.01.23 |
申请号 |
MX2006PA13413 |
申请日期 |
2005.05.19 |
申请人 |
MEDAREX, INC. |
发明人 |
GUERLAVAIS, VINCENT;BOYD, SHARON;CHEN, LIANG;GANGWAR, SANJEEV;HORGAN, KILIAN;LI, ZHI-HONG;SUFI, BILAL |
分类号 |
A61K31/403;A61K49/18;C07D403/14;C07D405/14;C07D417/14;C07D487/04 |
主分类号 |
A61K31/403 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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