| 摘要 |
FIELD: pharmacy. ^ SUBSTANCE: invention relates to a chew with cover used fir delivery of nicotine in a subject in any form. Proposed chew comprises at least one buffered or an unbuffered core, nicotine in the amount 0.05-10 mg as measured for a free nicotine base and/or nicotine-simulating agent, at least one cover layer wherein one cover layer comprises a buffer. Also, invention proposes a method for delivery of nicotine in any form, method for decreasing for smoking dependence or using tobacco, and using this chew for providing rapid assimilation of nicotine through mucosa in mouth cavity of a subject. Invention provides the more rapid assimilation of nicotine by mucosa in mouth cavity and reducing amount of swallowed nicotine and its accumulation in digestive tract. ^ EFFECT: improved and valuable properties of chew. ^ 41 cl, 2 tbl, 5 ex |
