| 摘要 |
FIELD: chemical and pharmaceutical and cosmetic industries, in particular composition and intermediates containing betulin and/or derivatives thereof as biologically active components. ^ SUBSTANCE: claimed additive contains betulin and/or derivatives thereof, vegetable oil, and surfactants. As surfactants it contains mixture of hydrophilic and lipophylic surfactants in ratio of 1:(0.65-4.0), respectively. Hydrophilic surfactants are selected from group containing oxyethylated alcohols, oxyethylated natural or hydrogenised castor oil, oxyethylated sorbitane and fat acid esters; and lipophylic surfactants are selected from group containing glycerol asters of fat acids, oxyethylated fat acids or alcohols; sorbitane and fat acid esters; emulsified wax, high fat alcohols, apian wax. As vegetable oil olive, soybean or castor oil is used. Also disclosed is method for production of said bioactive additive including treatment of betulin and/or derivatives thereof using vegetable oil by addition under stirring of dry betulin or derivative thereof into preliminary melted mixture of hydrophilic and lipophylic surfactants. Then vegetable oil is added, mixture is heated up to 100-120°C, conditioned to full dissolution, obtained solution is filtered in hot state and cooled. ^ EFFECT: effective bioactive additive with maximal distribution of surfactants on skin surface due to high disperse colloidal state of betulin and/or derivatives thereof. ^ 11 cl, 2 tbl |
