| 摘要 |
FIELD: medicine, pharmacology, pharmacy. ^ SUBSTANCE: invention relates to agent based on flesh-colored passionflower (Passiflora incarnate L.) herb extractive substances used as a sedative agent. Agent is made as a tablet and its core comprises flesh-colored passionflower dry alcoholic extract and accessory substance: lactose, potato starch, low-molecular polyvinylpyrrolidone, magnesium basic carbonate and magnesium stearate. Core of a tablet is covered by envelope comprising hydroxypropylmethylcellulose, polyethylene glycol-600, dye azorubin and titanium dioxide and these components are taken in the definite ratio. Method for preparing the sedative agent involves the following steps: flesh-colored passionflower dry sprouts with leaves are treated with alcohol in the ratio raw - extractant = 1:2, dried and prepared extract is mixed with lactose, potato starch and magnesium carbonate. Prepared mixture is wetted with low-molecular polyvinylpyrrolidone followed by successive wet granulation, drying granules, dry granulation, granules are powdered, tabletted and prepared tablet core is covered by envelope. Used raw is ground preliminary and dried at temperature 50-60°C. The expressed pharmacological activity of agent is caused by the presence of complex of biologically active substances of phenolic nature, vitamins, trace elements and other natural compounds. ^ EFFECT: improved preparing method of agent. ^ 4 cl
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