SUSTAINED-RELEASE TABLET CONTAINING PAROXETINE HYDROCHLORIDE AND MANUFACTURING METHOD THEREOF

摘要

A sustained-release tablet comprising paroxetine hydrochloride is provided to show low initial discharge rate of the paroxetine hydrochloride and be able to discharge the paroxetine hydrochloride at almost zero-order speed for about 12 hours. The sustained-release tablet comprises paroxetine hydrochloride, a high viscous polymer such as a high viscous hydroxypropylmethylcellulose, a mixture polymer consisting of polyvinyl acetate and povidone in a weight ratio of 8:2 and ethyl cellulose, a low viscous hydroxypropylmethylcellulose, and a pharmaceutically acceptable excipient such as a mixture of mannitol and lactose.