MONOMETHYLVALINE COMPOUNDS HAVING PHENYLALANINE CARBOXY MODIFICATIONS AT THE C-TERMINUS
摘要
<p>Auristatin peptide analogs of MeVal-Val-Dil-Dap-Phe (MMAF) having a carboxylic acid equivalent at the C-terminal phenylalanine were prepared and attached to ligands through various linkers, including maleimidocaproyl-val-cit-PAB. The resulting ligand drug conjugates were active in vitro and in vivo.</p>
申请公布号
WO2007008848(A2)
申请公布日期
2007.01.18
申请号
WO2006US26809
申请日期
2006.07.07
申请人
SEATTLE GENETICS, INC.;DORONINA, SVETLANA O.;KLINE, TONI BETH;JEFFREY, SCOTT;SENTER, PETER D.;MEYER, DAMON
发明人
DORONINA, SVETLANA O.;KLINE, TONI BETH;JEFFREY, SCOTT;SENTER, PETER D.;MEYER, DAMON