| 摘要 |
<p>The present invention relates to a method of determining P-glycoprotein expression and/or function for a patient with solid tumors, leukemias, and other malignancies. The invention also relates to using a P-glycoprotein expression and/or function diagnostic in conjunction with methods for treating solid tumors, leukemias, and other malignancies with a chemotherapeutic agent in combination with zosuquidar. The methods are particularly effective in treating acute myelogenous leukemia, metastatic breast cancer, and other cancers expressing P-glycoprotein, wherein the P-glycoprotein expression and/or function is used to select a treatment option for the patient.</p> |
| 申请人 |
KANISA PHARMACEUTICALS, INC.;SIKIC, BRANIMIR;HOTH, DANIEL;SOCKS, DAVID;GLENN, SCOTT;MARCELLETTI, JOHN;WALSH, MICHAEL, J.;MULTANI, PRATIK, S. |
发明人 |
SIKIC, BRANIMIR;HOTH, DANIEL;SOCKS, DAVID;GLENN, SCOTT;MARCELLETTI, JOHN;WALSH, MICHAEL, J.;MULTANI, PRATIK, S. |
