STABLE QUANTITATION AND DETECTION OF IMMUNE RESPONSE LEVELS WITH NON-ZERO BACKGROUND PEPTIDES
摘要
The invention relates to a kit comprising MHC Class I and Class II HLA-coated beads containing specific antigenic peptides for binding to antigen-specific T cells and the appropriate negative control peptides. Also provided are methods for making the coated beads and methods for use. The application of these beads goes to the stimulation of peripheral blood cell populations and in vzYro-stimulated culture for the elicitation of functional activities such as cell activation and signaling, cytokine secretion, proliferation and cytotoxicity activity.
申请公布号
WO2007008488(A2)
申请公布日期
2007.01.18
申请号
WO2006US25982
申请日期
2006.07.05
申请人
HENRY M. JACKSON FOUNDATION FOR THE ADVANCEMENT OF MILITARY MEDICINE, INC.;PONNIAH, SATHIBALAN;PEOPLES, GEORGE, E.;STORRER, CATHERINE, E.;FLORA, MICHAEL
发明人
PONNIAH, SATHIBALAN;PEOPLES, GEORGE, E.;STORRER, CATHERINE, E.;FLORA, MICHAEL