GFAP-BASED GENE THERAPY FOR TREATMENT OF RETINAL DISEASES
摘要
Compositions and methods for reducing neovascularization. Purified nucleic acid constructs and vectors encoding an anti-angiogenic protein operably linked to a GFAP promoter. Vectors can include at least one hypoxia regulated element, enhancer element and silencer element. Gene therapy methods for reducing, delaying or preventing neovascularization based on the nucleic acid constructs and vectors.
申请公布号
WO2005113017(A3)
申请公布日期
2007.01.18
申请号
WO2005US14132
申请日期
2005.04.22
申请人
FLORIDA ATLANTIC UNIVERSITY;DOREY, KATHLEEN, C.;BLANKS, JANET, C.;PRENTICE, HOWARD
发明人
DOREY, KATHLEEN, C.;BLANKS, JANET, C.;PRENTICE, HOWARD