A method for identifying a compound that inhibits the NAD<SUP>+</SUP>-dependent deacetylase activity of a SIR2 protein is disclosed. These compounds are useful for the treatment of cancers and other diseases, through the activation of silenced genes, through the promotion of apoptosis in cancerous cells, and through the inhibition of transcriptional repressor activity in oncogenes.
申请公布号
WO03046207(A3)
申请公布日期
2007.01.18
申请号
WO2002US38434
申请日期
2002.11.26
申请人
FRED HUTCHINSON CANCER RESEARCH CENTER;BEDALOV, ANTONIO;GOTTSCHLING, DANIEL, E.;SIMON, JULIAN