HETEROCYCLIC SULFONAMIDE DERIVATIVES AS INHIBITORS OF FACTOR XA

摘要

The invention relates to heterocyclic derivatives of formula (I), Chemical formula should be inserted here. Please see paper copy wherein R<SUP>1</SUP> is hydrogen or C<SUB>1-3</SUB>alkyl; R<SUP>2</SUP> is selected from hydroxy, C<SUB>1-5</SUB>alkyl, carboxy, cyano, tetrazolyl, N-C<SUB>1-5</SUB>alkyltetrazolyl, oxazolyl, C<SUB>1-5</SUB>oxazolyl, isoxazolyl, C<SUB>1-5</SUB>isoxazolyl, hydroxyC<SUB>1-5</SUB>alkyl, carboxy C<SUB>1-5</SUB>alkyl, C<SUB>1-5</SUB>alkoxyoxo C<SUB>1-5</SUB>alkyl, carbamoyl, C<SUB>1-5</SUB>alkylcarbamoyl, di(C<SUB>1-5</SUB>alkyl)carbamoyl, C<SUB>1-5</SUB>alkylcarbamoyl C<SUB>1-4</SUB>alkyl, hydroxy C<SUB>1-5</SUB>alkylcarbamoyl, C<SUB>1-5</SUB>alkoxy C<SUB>1-5</SUB>alkylcarbamoyl; -C<SUB>1-5</SUB>alkyl-Y<SUP>1</SUP>, -COOCHR<SUP>17</SUP> R<SUP>18</SUP> and -CON R<SUP>17</SUP> R<SUP>18</SUP>; and R<SUP>3</SUP> is hydrogen or halogen; or a pharmaceutically acceptable salt thereof, said compounds possess antithrombotic and anticoagulant properties and are accordingly useful in methods of treatment of humans or animals. The invention also relates to processes for the preparation of the compounds, to their use, to pharmaceutical compositions comprising them, to their use in the manufacture of medicaments for use in the production of an antithrombotic or anticoagulant effect, and to combinations comprising them.