| 摘要 |
<p>The invention relates to compounds of formula (I), Chemical formula should be inserted here. Please see paper copy wherein R<SUP>1</SUP> is hydrogen, C<SUB>1-3</SUB>alkyl, R<SUP>5</SUP>R<SUP>6</SUP> aminoC<SUB>1-5</SUB>alkyl, where R<SUP>5</SUP> and R<SUP>6</SUP> are each independently selected from hydrogen and C<SUB>1-3</SUB>alkyl, or R<SUP>5</SUP> and R<SUP>6</SUP> may, together with the nitrogen to which they are attached, form a five- or six-membered heterocyclic ring, where said heterocyclic ring has 0 or 1 additional heteroatom; n is 1 or 2; each R<SUP>2</SUP> are independently selected from hydrogen, oxo and C<SUB>1-3</SUB>alkyl, R<SUP>3</SUP> is an indolyl, and R<SUP>4</SUP> a hydrogen or a halogen; or a pharmaceutically acceptable salt thereof, said compounds possess antithrombotic and anticoagulant properties and are accordingly useful in methods of treatment of humans or animals. The invention also relates to processes for the preparation of the compounds, to their use, to pharmaceutical compositions comprising them, to their use in the manufacture of medicaments for use in the production of an antithrombotic or anticoagulant effect, and to combinations comprising them.</p> |
