CLEAR PHARMACEUTICAL AQUEOUS MICROEMULSION COMPRISING PROPOFUOL AND PROCESS FOR PREPARATION
摘要
<p>The present invention concerns a clear pharmaceutical aqueous emulsion composition which comprises Propofol and a surfactant system and which is particularly usable for a safe administration through intravenous injection. A composition according to the invention is characterized in that said surfactant system comprises in combination at least one pharmaceutically acceptable monovalent metal salt of a fatty acid having from 5 to 23 carbon atoms, and at least one polyethylene glycol hydroxystearate. This combination allows to use a mass ratio (w/w) surfactant system / Propofol which is less than 4 and preferably less than or equal to 2.8, while obtaining such a clear composition.</p>
申请公布号
WO2007006334(A1)
申请公布日期
2007.01.18
申请号
WO2005EP08739
申请日期
2005.07.08
申请人
PHYSICA PHARMA;POUGNAS, JEAN-LUC;BROUSSAUD, OLIVIER;CALVET, NICOLAS;COMTAT, SOPHIE
发明人
POUGNAS, JEAN-LUC;BROUSSAUD, OLIVIER;CALVET, NICOLAS;COMTAT, SOPHIE