GLYCEROL BRANCHED POLYETHYLENE GLYCOL HUMAN GROWTH HORMONE CONJUGATES, PROCESS FOR THEIR PREPARATION, AND METHODS OF USE THEREOF

摘要

The present invention relates to PEGylation of human Growth Hormone (hGH) using a glycerol branched PEG. The present invention also relates to processes for the PEGylation of hGH. In addition, the present invention relates to pharmaceutical compositions comprising the PEGylated hGH. A further embodiment is the use of the PEGylated hGH for the treatment of growth and development disorders.