| 发明名称 |
Production of pseudotyped recombinant AAV virions |
| 摘要 |
Vectors that encode Adeno-Associated Virus (AAV) Rep and Cap proteins of different serotypes and Adenovirus transcription products that provide helper functions were used to produce pseudotyped recombinant AAV (rAAV) virions. Purification methods generated pseudotyped rAAV virion stocks that were 99% pure with titers of 1x10<SUP>12</SUP>-1x10<SUP>13 </SUP>vector genomes/ml.
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| 申请公布号 |
US2007015238(A1) |
申请公布日期 |
2007.01.18 |
| 申请号 |
US20030456423 |
申请日期 |
2003.06.05 |
| 申请人 |
SNYDER RICHARD O;ZOLOTUKHIN SERGIE;SAKAI YOSHIHISA;BYRNE BARRY J;POTTER MARK R;ZOLOTUKHIN IRINE;LOILER SCOTT;CHIODO VINCE A;MUZYCZKA NICHOLAS;HAUSWIRTH WILLIAM;FLOTTE TERENCE R;BURGER CORINNA;RODRIGUEZ EDGARDO |
发明人 |
SNYDER RICHARD O.;ZOLOTUKHIN SERGIE;SAKAI YOSHIHISA;BYRNE BARRY J.;POTTER MARK R.;ZOLOTUKHIN IRINE;LOILER SCOTT;CHIODO VINCE A.;MUZYCZKA NICHOLAS;HAUSWIRTH WILLIAM;FLOTTE TERENCE R.;BURGER CORINNA;RODRIGUEZ EDGARDO |
| 分类号 |
C12P21/06;C12N5/06;C12N7/00;C12N15/861;C12N15/864 |
主分类号 |
C12P21/06 |
| 代理机构 |
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