CLEAR PHARMACEUTICAL AQUEOUS MICROEMULSION COMPRISING PROPOFOL AND PROC ESS FOR PREPARATION

摘要

The present invention concerns a clear pharmaceutical aqueous emulsion co mposition which comprises Propofol and a surfactant system and which is part icularly usable for a safe administration through intravenous injection. A c omposition according to the invention is characterized in that said surfacta nt system comprises in combination at least one pharmaceutically acceptable monovalent metal salt of a fatty acid having from 5 to 23 carbon atoms, and at least one polyethylene glycol hydroxystearate. This combination allows to use a mass ratio (w/w) surfactant system / Propofol which is less than 4 an d preferably less than or equal to 2.8, while obtaining such a clear composi tion.