发明名称 |
STEM AND PROGENITOR CELL EXPANSION BY EVI, EVI-LIKE GENES AND SETBP1 |
摘要 |
A method of increasing cell proliferation by modulating levels of EVI and related genes. Activation of EVI-1, PRDM16, or SETBP1 can increase the proliferation rate, self renewal and/or in vitro and/or in vivo survival and/or engraftment of human cells, either in vitro or in vivo. The gene modulation can be performed by various means, including traditional cloning methods and retroviral-based gene activation methods. The method can also be used to more efficiently deliver gene-corrected cells to a patient in need of treatment. |
申请公布号 |
WO2007008309(A2) |
申请公布日期 |
2007.01.18 |
申请号 |
WO2006US21413 |
申请日期 |
2006.06.01 |
申请人 |
CHILDREN'S HOSPITAL MEDICAL CENTER;VON KALLE, CHRISTOF;SCHMIDT, MANFRED;GREZ, MANUEL |
发明人 |
VON KALLE, CHRISTOF;SCHMIDT, MANFRED;GREZ, MANUEL |
分类号 |
C12N15/10;C12N5/10;C12N15/861 |
主分类号 |
C12N15/10 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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