发明名称 |
Nucleic acid molecules, polypeptides and uses therefor, including diagnosis and treatment of Alzheimer's disease |
摘要 |
The present invention provides methods and compositions for screening, diagnosis and prognosis of Alzheimer's disease, for monitoring the effectiveness of Alzheimer's disease treatment, and for drug development. Alzheimer's Disease-Associated Features (AFs), detectable by two-dimensional electrophoresis of cerebrospinal fluid, serum or plasma are described. The invention further provides Alzheimer's Disease-Associated Protein Isoforms (APIs) detectable in cerebrospinal fluid, serum or plasma, preparations comprising isolated APIs, antibodies, pharmaceutical compositions, diagnostic and therapeutic methods, and kits comprising or based on the same.
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申请公布号 |
US2007015217(A1) |
申请公布日期 |
2007.01.18 |
申请号 |
US20050078000 |
申请日期 |
2005.03.11 |
申请人 |
DURHAM L K;FRIEDMAN DAVID L;CHANDRASIRI HERATH HERATH MUDI;KIMMEL LIDA H;PAREKH RAJESH B;POTTER DAVID M;ROHLFF CHRISTIAN;SILBER B M;STIGER THOMAS R;SUNDERLAND P T;TOWNSEND ROBERT R;WHITE W F;WILLIAMS STEPHEN A |
发明人 |
DURHAM L. K.;FRIEDMAN DAVID L.;CHANDRASIRI HERATH HERATH MUDIYANSELAGE A.;KIMMEL LIDA H.;PAREKH RAJESH B.;POTTER DAVID M.;ROHLFF CHRISTIAN;SILBER B. M.;STIGER THOMAS R.;SUNDERLAND P. T.;TOWNSEND ROBERT R.;WHITE W. F.;WILLIAMS STEPHEN A. |
分类号 |
G01N27/62;G01N33/567;A61K31/7088;A61K39/395;A61K48/00;A61P25/28;C07K16/18;C12N1/15;C12N1/19;C12N1/21;C12N5/10;C12N9/00;C12N15/09;C12P21/08;C12Q1/02;C12Q1/68;G01N27/447;G01N33/15;G01N33/53;G01N33/68;G01N37/00 |
主分类号 |
G01N27/62 |
代理机构 |
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代理人 |
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