| 摘要 |
<p>The invention relates to compounds of formulae
wherein
R 1 and R 2 are independently from each other and signify lower alkoxy, lower alkenyloxy, benzyloxy, hydroxy, ۥOCH(CH 3 )OC(O)-lower alkyl or ۥOCH 2 C(O)N(R 3 )(R 4 ), with the proviso that only one of R 1 or R 2 may be hydroxy;
R 3 and R 4 are independently from each other and signify hydrogen, lower alkyl, lower alkenyl or cycloalkyl; or
R 1 and R 2 form together with the carbon atom, to which they are attached the linking group X, wherein
X is ۥO(CH 2 ) n CH=CH(CH 2 ) n O- or -O(CH 2 ) m O-;
n is 1, 2 or 3; and
m is 4-8.
as well as pharmaceutically acceptable salts of said compounds. Compounds of the present invention can be used for the treatment of diseases where Serum Amyloid P Component depletion has a beneficial effect, in particular in the treatment or prevention of all forms of central and systemic amyloidosis.</p> |
