| 摘要 |
The present invention provides a novel amide derivative having a matrix metalloproteinase inhibitory activity, and useful as a pharmaceutical agent, which is a compound represented by the formula (I) wherein ring A is an optionally substituted, nitrogen-containing heterocycle, ring B is an optionally substituted monocyclic homocycle or an optionally substituted monocyclic heterocycle, Z is N or NR1 (R1 is a hydrogen atom or an optionally substituted hydrocarbon group), - - - is a single bond or a double bond, R2 is a hydrogen atom or an optionally substituted hydrocarbon group, X is an optionally substituted spacer having 1 to 6 atoms, ring C is (1) an optionnally substituted homocycle or (2) an optionally substituted heterocycle other than a ring represented by (II) (X' is S, O, SO, or CH2), and at least one of ring B and ring C has substituent(s), provided that N-{(1S, 2R)-1-(3, 5-difluorobenzyl) -3-[(3-ethylbenzyl) amino] -2-hydroxypropyl} -5, 6-dimethyl-4 -oxo-1, 4-dihadrothieno[2, 3-d]pyrimidine- 2-carboxamide is excluded, or a salt thereof. |
