IMMUNIZATION REGIMEN WITH E4-DELETED ADENOVIRUS PRIME AND E1-DELETED ADENOVIRUS BOOST

摘要

An immunization regimen is provided which involves priming with an E1, E4-deleted adenovirus and boosting with an E1-deleted adenovirus. The second administered adenovirus has a capsid of a serotype which is not cross-reactive with the previously administered adenovirus. Each of the adenoviruses carries a heterologous expression cassette comprising a nucleic acid sequence encoding a product for inducing an immune response under the control of regulatory control sequences which direct expression of the product. The expression cassettes can have the same or different regulatory control sequences. Further, a product containing the adenoviruses necessary to perform the immunization regimen is provided.