| 摘要 |
The invention relates to an improved drug-delivery endoprosthetic device for insertion at a vascular site via catheter placement at the site, comprising: a polymer member capable of expanding from a contracted to a stable, expanded state when the polymer member is exposed to a selected stimulus, said member having a pharmaceutical composition comprising one or more active ingredients selected from the group consisting of agents to inhibit or at least reduce excessive proliferation of vessel wall cells, agents to enhance the downstream perfusion of tissue, agents to promote and/or to enhance the neoformation of capillaries, agents designed to modulate the amount or activity of coagulation factors, agents to reduce the amount of Thrombin- and / or Fibrinformation, embedded therein for release from the member, with such in its expanded state, a structural member on which the polymer member is carried, for coexpansion with the polymer member from a contracted state to an expanded state when the device is exposed to said stimulus, where the device can be delivered from a catheter, with the structural and polymer members in their contracted states, and is adapted to be held in a vessel at the vascular target site by radial pressure against the wall of the vessel, with the structural and polymer members in their expanded states the improvement wherein is that said pharmaceutical composition comprises at least one pyrimido-pyrimidine compound selected from dipyridamole, mopidamol and the pharmaceutically acceptable salts thereof, optionally in combination with one or more other antithrombotic agents, agents to enhance lysis of fibrin, agents to locally arrest cell proliferation in a reversible or in an irreversible manner, a gene transfer protein, an inhibitor of metallo-protease, a statin, an antifungal antibiotic such as rapamycin, an ACE inhibitor, an Angiotensin II antagonist, an ADP receptor inhibitor, a Ca-antagonist and/or a lipid-lowering agent. <IMAGE> |
