| 摘要 |
A novel pyrrolidine derivative represented by the formula (I) or a salt thereof. They have excellent DPP- IV inhibitory activity and excellent internal behavior. Because of these functions, the compound or salt is useful for the treatment and/or prevention of insulin-dependent diabetes mellitus (type 1 diabetes), especially noninsulin-dependent diabetes mellitus (type 2 diabetes), insulin-resistant diseases, obesity, etc. [Chemical formula] (I) [In the formula, -A- represents a single bond, -O-, -S-, -NH-, or -N(lower alkyl)- ; and -B represents lower alkyl, lower alkenyl, lower alkynyl, cycloalkyl, aryl, or a nonaromatic heterocycle or aromatic heterocycle, provided that these groups each may be substituted.]. ® KIPO & WIPO 2007
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