发明名称 |
ANTIBODIES AND MOLECULES DERIVED THEREFROM THAT BIND TO STEAP-1 PROTEINS |
摘要 |
Antibodies and molecules derived therefrom that bind to novel STEAP-1 protein, and variants thereof, are described wherein STEAP-1 exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in the cancers listed in Table I. Consequently, STEAP-1 provides a diagnostic, prognostic, prophylactic and/or therapeutic target for cancer. The STEAP-1 gene or fragment thereof, or its encoded protein, or variants thereof, or a fragment thereof, can be used to elicit a humoral or cellular immune response; antibodies or T cells reactive with STEAP-1 can be used in active or passive immunization |
申请公布号 |
EP1742966(A2) |
申请公布日期 |
2007.01.17 |
申请号 |
EP20040750565 |
申请日期 |
2004.04.22 |
申请人 |
AGENSYS, INC. |
发明人 |
JAKOBOVITS, AYA;ETESSAMI, SOUDABEH;CHALLITA-EID, PIA, M.;PEREZ-VILLAR, JUAN, J.;MORRISON, KAREN, J.;JIA, XIAO-CHI;FARIS, MARY;GUDAS, JEAN;RAITANO, ARTHUR, B. |
分类号 |
C07K16/30;A61K39/395;A61K45/06;A61K47/48;A61K51/10;C07K16/00 |
主分类号 |
C07K16/30 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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