R-ENANTIOMER OF N-PROPARGYL-1-AMINOINDAN, SALTS, COMPOSITIONS AND USES THEREOF

摘要

The subject invention provides R(+)-N-propargyl-1-aminoindan and pharmaceuti cally acceptable salts thereof, as well as pharmaceu- tical compositions containing same. Tbe subject invention also provides meth ods of treating a subject afflicted with Parkinson's dis ease, a memory disorder, dementia, depression, hyperactive syndrome, an affective illness, a neurodegenerative disease, a neurotoxic injur y, brain ischemia, a head trauma injury, a spinal trauma injury, schizophrenia, an attention deficit disorder, multiple sclerosis, or w ithdrawal symptoms, using R(+)-N-propargyl-1-aminoindan or the pharmaceutically accept able salt of the subject invention. The subject inventio n further provides a method of preventing nerve damage in a subject. Finally, the subject invention provides methods of preparing R(+) -N- propargyl-1-aminoindan, a salt thereof, and racemic N-propargyl-1-aminoindan .