A COMPOUND COMPRISING PRODIGIOSIN ISOLATED FROM SERRATIA MARCESCENCE B-1231 KCTC 0386BP FOR PROVENTION AND TREATMENT OF ACUTE GRAFT-VERSUS-HOST DISEASE
摘要
A composition comprising prodigiosin is provided to selectively inhibit the proliferation of T cell and have the Immunosuppressant activity of not influencing on signaling after IL-2 recipient is combined with the T-cell, thereby being effectively used for preventing and treating acute graft-versus-host disease. The composition for preventing or treating acute graft-versus-host disease comprises prodigiosin isolated from Serratia marcescence B-1231 KCTC 0386BP as an effective ingredient. The prodigiosin in the composition is able to be administered together with cyclosporine A so as to treat the acute graft-versus-host disease.
申请公布号
KR20070007579(A)
申请公布日期
2007.01.16
申请号
KR20050062287
申请日期
2005.07.11
申请人
KOREA RESEARCH INSTITUTE OF BIOSCIENCE AND BIOTECHNOLOGY
发明人
KIM, HWAN MOOK;HAN, SANG BAE;LEE, CHANG WOO;LEE, KI HOON;PARK, SUNG KYU;LEE, KI HO;KANG, JONG SOON;YOON, WON KEE;KIM, YOUNG KOOK