USE OF 11BETA-4-ACETYLPHENYL-17BETA-HYDROXY-17ALPHA-1,1,2,2,2-PENTAFLUOROETHYLESTRA-4,9-DIEN-3-ONE FOR THE PREPARATION OF A MEDICAMENT FOR THE TREATMENT OF BREAST, OVARIAN, ENDOMETRIAL CANCER, MYELOMA AND MENINGIOMA

摘要

The present invention relates to methods and uses for inducing apoptosis in a cell, in particular a breast cancer cell, by the administration of antiprogestins, in particular the antiprogestin 11 beta -(4-acetylphenyl)-17 beta -hydroxy-17 alpha -(1,1,2,2,2-pentaf luoroeth yl)-estra-4,9-dien-3-one or a pharmaceutically acceptab le derivative or analogue thereof. The invention further relates to a treatment of cancer wherein an indicator of high risk is an increased amount of tumor cells in the S-phase of the cell cycle, said treatment comprising an antiprogestin, in particular the antiprogestin 11 beta -(4-acetylphenyl)-17 beta -hydroxy-17 alpha -(1, 1,2, 2,2- pentafluoroethyl)-estra-4,9-dien-3-one or a pharmaceutically acceptable derivative or analogue thereof.