PROCEDURE FOR COMBINED MEDICAMENTOUS CORRECTION OF VASCULAR ENDOTHELIAL DYSFUNCTION IN PATIENTS WITH DISEASES OF KIDNEYS

摘要

The procedure for the combined medicamentous correction of the vascular endothelial dysfunction in the patients with the diseases of kidneys provides for the biochemical examination of blood serum prior to the treatment, the assessment of the control indices of the vascular endothelial dysfunction, and the basic therapy. The concentration of nitrosothiol as the stable metabolite of nitric oxide (NO) is assessed as the control index of the functional state of the endothelium. The concentration of malonic dialdehyde (MDA) and SH groups is assessed as the index of the oxidative stress and the bioavailability of nitric oxide. MDA to SH groups is calculated. The content of interleukin-1? characterizes the anti-inflammatory activity. The control indices are assessed prior to the treatment and after two-week treatment. The decrease in the valuesassessed by less than 30% is an indication for the use of hypolipidemic drug, non-saturated fatty acids of omega-3 class at the therapeutically effective doses for the following two months.