BENZOIC ACID DERIVATIVES THAT ARE MODULATORS OR AGONISTS OF GLYR

摘要

Compounds of formula I, wherein Y = H, -OH, halo, -OC_1-6alkyl, -C_1-6alkyl, the two latter optionally substituted with halo, -CN, -OH, -CF₃, -NH₂; Rl = -C_3-6cycloaUcyl, heterocycloalkyl, aryl, alkylaryl, heteroaryl, -C_3-6-alkyl, optionally substituted with halo, -CN, -OH, -CF₃, -OCF₃, -NH₂, -CONH²; M = -C(O)-, -C(H₂)-, -CH(OR³)-, -N(R^a)-, -S(O)_r-, heteroaryl and a bond; wherein R^a = H or C_1-6alkyl and r = 0, 1 or 2; R2 = H, halo, -CN, or D = -C_1-6alkyl, C_3-6cycloalkyl, heterocycloalkyl, -N(CH₃)₂, aryl, alkylaryl, heteroaryl, and heterocyclic groups; where D is optionally substituted with G = halo, -NO₂, -CN, -OH, -CF₃, -OCF₃, -NH₂, -CONH₂, -COOH, aryl, heteroaryl, heterocyclic groups, -C_1-6alkyl, -C_1-6alkoxy, heterocycloalkyl, and C_1-6alkylcarboxylate; where D may be connected to G by L = -C(O)-, -S-, or -S(O₂)-; and G may be further substituted with substituents selected from halo, -NO₂, -CN, -OH, -CH₃, -OCH₃, -CF₃, -OCF₃, -NH₂, -CONH₂, -COOH, C_1-6alkylcarboxylate; and R3 = -OH or C_1-6alkoxy.