Core 2 GlcNAc-T inhibitors

摘要

A method of treating a subject in need of therapy for a condition involving detrimental activity of the enzyme core 2 GlcNAc-T is provided, comprising administration of a therapeutically effective amount of an inhibitor of core 2 GlcNAc-T of formula I to a patient in need thereof wherein: R¹ is H, C_1-6 alkyl, C_1-6 hydroxyalkyl, C_1-6 alkoxy or C_1-6-alkoxy-C_1-6-alkyl; R² is H, -OH or C_1-6 alkoxy; S¹ and S² are independently selected saccharide moieties; and Z is a steroid moiety; or a pharmaceutically acceptable salt, ether or ester thereof.