Multiple sclerosis therapy and diagnosis

摘要

A method of treatment of Multiple Sclerosis in a subject is disclosed comprising administering to the subject a compound capable of reducing the activity of Core 2 GlcNAc-T. Also disclosed is a method of diagnosing Multiple Sclerosis in a subject and a method of determining the utility of a test substance for use in the treatment of Multiple Sclerosis comprising determining the ability of the substance to inhibit the activity of Core 2 GlcNAc-T.