| 发明名称 |
CONSTRAINED HIV ENVELOPE-BASED IMMUNOGEN THAT SIMULTANEOUSLYPRESENTS RECEPTOR AND CORECEPTOR BINDING SITES |
| 摘要 |
<p>The present invention relates to a soluble binding complex comprising a s oluble gp120 trimer, in which only two gp120 protomers have CD4 binding site s occupied by interconnecting CD4 mimetic moieties, thereby allowing for the exposure of CD4-induced epitopes on the mimetic-bound protomers and an unoc cupied CD4 binding site on the third gp120 protomer.</p> |
| 申请公布号 |
CA2656741(A1) |
申请公布日期 |
2007.01.11 |
| 申请号 |
CA20062656741 |
申请日期 |
2006.07.06 |
| 申请人 |
UNIVERSITY OF MARYLAND BIOTECHNOLOGY INSTITUTE |
发明人 |
WANG, LAI-XI;LEWIS, GEORGE;DEVICO, ANTHONY L. |
| 分类号 |
A61K39/00;A61K39/12;A61K39/21;C07K1/00;C07K14/00;C12N7/00;C12N7/01 |
主分类号 |
A61K39/00 |
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