发明名称 |
Gene transfer with adenoviruses having modified fiber proteins |
摘要 |
Methods and compositions for transducing tumor cells using adenoviral vectors which comprise: a chimeric or modified adenovirus fiber protein and the coding sequence for a therapeutic agent, are provided. The chimeric or modified adenovirus fiber protein has at least a portion of an adenovirus fiber shaft of a first serotype and at least a portion of an adenovirus fiber head of a second serotype wherein the adenovirus comprising such a chimeric or modified adenovirus fiber protein exhibits enhanced transduction of tumor cells.
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申请公布号 |
US2007010016(A1) |
申请公布日期 |
2007.01.11 |
申请号 |
US20060371488 |
申请日期 |
2006.03.09 |
申请人 |
MCCELLAND ALAN;STEVENSON SUSAN;GORZIGLIA MARIO;VANIN ELIO |
发明人 |
MCCELLAND ALAN;STEVENSON SUSAN;GORZIGLIA MARIO;VANIN ELIO |
分类号 |
C12N15/861;C12N7/00 |
主分类号 |
C12N15/861 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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