[1, 2, 4] TRIAZOLO [1, 5-A] PYRIMIDINE DERIVATIVES AS CHROMATOGRAPHIC ADSORBENT FOR THE SELCTIVE ADSORPTION OF IGG

摘要

The present invention relates to a chromatographic adsorbent for selectively adsorbing IgG, comprising the following formula (I) and its corresponding enol-form, wherein X represents O, S, or NH; R¹ represents H, C_1-6 alkyl, C_1-6alkoxy, C_1-6 alkoxy-C_1-6 alkyl, Ar, -C(O)NHR³, -C(O)-R³ or halo; R² represents H, C_1-3 alkyl or halo; R³ represents H, C_1-6 alkyl, C_1-6 alkoxy, C_1-6 alkoxy-C_1-6alkyl or Ar; n represents 0, 1, 2 or 3; Y represents a carrier. The present invention also relates to a method of producing said adsorbent as well as use thereof for separating substances by affinity chromatography.