MODULATION OF AUTOPHAGY BY CALPAIN INHIBITION

摘要

The present invention relates to finding that the inhibition of calpain induces autophagy in eukaryotic cells through an mTOR independent pathway. Methods and materials are provided for the treatment of diseases which are ameliorated by the induction of autophagy by inhibiting calpain such as neurodegenerative and infections diseases . Also provided are screening methods for identifying compounds which inhibit calpain and may be useful for treating such conditions .